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demonstrated an in vitro hydrolysis of erythrocytic spectrin by plasmepsin II (Le Bonniec et al., 1999), which involves cleaving mainly within the SH3 motif of the spectrin a-subunit by aspartic protease(s)

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Structural context for why an isolated C-terminal fragment does not act at the GH receptor: site 1 of the hGH-receptor interface is dominated by helix 4 and includes Phe176, Arg178 and Cys182 — residues inside the 176-191 span

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